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Nava Zaarur Phones & Addresses

  • Brookline, MA

Resumes

Resumes

Nava Zaarur Photo 1

Phd At Boston University School Of Medicine

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Position:
PhD at Boston University School of Medicine
Location:
Greater Boston Area
Industry:
Biotechnology
Work:
Boston University School of Medicine
PhD
Nava Zaarur Photo 2

Phd At Bu

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Position:
PhD at BU
Location:
Greater Boston Area
Industry:
Biotechnology
Work:
BU
PhD

Publications

Us Patents

Methods For Sensitizing Cancer Cells To Inhibitors

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US Patent:
20090062222, Mar 5, 2009
Filed:
Sep 29, 2006
Appl. No.:
12/088467
Inventors:
Michael Sherman - Newton MA,
Stuart K Calderwood - Chestnut Hill MA,
Nava Zaarur - Brookline MA,
Assignee:
TRUSTEES OF BOSTON UNIVERSITY - Boston MA
International Classification:
A61K 31/704
A61K 31/4375
A61K 31/336
A61K 31/395
A61K 31/69
A61K 31/517
A61K 31/4745
A61P 35/00
US Classification:
514 34, 514283, 514450, 514183, 514 64, 514267, 514294
Abstract:
The present invention is based on the discovery that inactivation of the heat shock response in cancer cells significantly enhances their sensitivity to proteasome and Hsp90 inhibitors. The inventors have discovered novel compounds which exhibit low toxicity, inhibit the heat shock protein response and sensitize cancer cells to anti-cancer therapies. In general, the heat shock protein inhibitors of the present invention share a common structure, namely a 2H-benzo[a]quinolizine tricyclic ring. Also encompassed are methods for a high throughput screen to identify heat shock inhibitors that sensitize cancer cells to anti-cancer therapies.
Nava Zaarur from Brookline, MA, age ~56 Get Report